dianabol side effects

Trade name : ghayr

International nonproprietary name : dianabol side effects

Oblong green biconvex tablets, film-coated, scored on one side and smooth on the other. At the turn of two layers are visible: sheath green and tablet mass almost white.

Pharmacotherapeutic group
activity against means.

Pharmacological properties

antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action consists in biochemical restoration of 5-nitro dianabol side effects intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro dianabol side effects DNA interacts with cells of microorganisms by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria.
It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis , Entamoeba histolytica, Lamblia spp., And obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatos , Bacteroides thetaiotaomicrori, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P.bivia, P.buccae, P.disiens), and some gram-positive bacteria ( Eubacterium spp., Clostridium). By dianabol side effects not sensitive aerobic microorganisms.

Pharmacokinetics
The absorption from the gastrointestinal tract – is high. Bioavailability – 90%. The maximum plasma concentration of about 30 mcg / ml is reached within 2 hours after administration of a single dose of 1.5 grams, which is reduced to 9 g / ml after 24 h and 2.5 g / ml after 48 hours.
The half-life (T1 / 2) – 12 – 14 hours Connection with the plasma protein -.. at least 15%
penetrates the blood-brain barrier.
excreted as metabolites by the kidneys (60 – 70%) and through the intestine (20 – 25%), about 5% of the dose excreted in unaltered. 85% of a single dose is excreted for five days.

Indications

 

  • Trichomoniasis;
  • all forms of amoebiasis (intestinal and extra-intestinal disease localization, including amebic liver abscess, amoebic dysentery, amoebiasis and asymptomatic);
  • giardiasis;
  • anaerobic bacterial infections (abdominal and gynecological infections caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., and other anaerobes sensitive dianabol side effects.
  • Treatment of Helicobacter pylori infection during peptic ulcer 12 duodenum or stomach in conjunction with the bismuth and the antibiotic drugs.
  • Prophylactic before surgery on the gastrointestinal tract and reproductive organs.Contraindications
    Hypersensitivity to dianabol side effects and other nitroimidazole derivatives, as well as other components of the preparation.
  • Leukopenia (including history).
  • Organic lesions of the central nervous system (including epilepsy).
  • Pregnancy (I trimester), lactation.
  • Children under 3 years of age (for a given dosage form).
  • Rare hereditary disorders such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption.Precautions
    Pregnancy (II-III trimesters), renal / hepatic failure.

    Dosing and Administration
    dianabol side effects taken inside after eating, squeezed small amounts of water. Trichomoniasis Adult: . 1 tablet 2 times a day (morning and evening) for 5 days women must also appoint dianabol side effects in the form of vaginal tablets. You can repeat the treatment if necessary. Between courses should take a break of 3-4 weeks to conduct repeated control laboratory tests. An alternative regimen is the appointment of 2 g once a patient and his sexual partner. The treatment is carried out simultaneously in both sexual partners. Children: The daily dose for children is 25 mg / kg body weight and is administered once.Amoebiasis Possible regimens:

    length of treatment daily dose
    Adults and children
    weighing more than 35 kg
    Children weighing up to 35 kg
    a) 3 days 3 tablets at once in the evening. When a body weight of 60 kg – 4 tablets (2 tablets in the morning and evening). 40 mg / kg of body weight in a single step
    b) 5-10 days 2 tablets (tso 1 tablet in the morning and evening) 25 mg / kg of body weight in a single step

    Adults:
    In asymptomatic amoebiasis 500 mg (1 tablet) 2-3 times a day for 5-7 days.
    In chronic amebiasis 500 mg (1 tablet) 3 times a day for 5-10 days.
    In acute amebic dysentery 1 5 g (3 tablets) 1 time per day.
    in liver abscess maximum daily dose of 2.5 or 1 g in 2-3 doses, over 3-5 days, in combination with antibiotics (tetracycline) and other therapies. Giardiasis Adults and children weighing more than 35 kg: 3 tablets once in the evening. children weighing less than 35 kg . 40 mg / kg once daily Duration of treatment is 1-2 days. Infections caused by anaerobic bacteria Adults: 500 mg ( 1-2. tablets) 3 times a day, during or after meals dianabol side effects may be used alone or in combination with other antibacterial agents. children: The daily dose for children is 10 mg / kg body weight, and is assigned two times a day. The average period treatment should not exceed 7 days. Prevention of infections caused by anaerobic bacteria (before surgery to the abdomen, in gynecology and obstetrics) First, 1 g (2 500 mg tablets) in a single dose, followed by 1 tablet 500 mg 2 times a day for 3-5 days. Eradication of Helicobacter pylori at 500 mg three times a day for 7 days (combination therapy, such as amoxicillin 2.25 g / d.).

     

    Side effects CNS: headache, dizziness, tremor, muscle rigidity, incoordination, seizures, sensory or mixed peripheral neuropathy, vertigo, sleep disturbances, fatigue, anxiety, irritability, temporary loss of consciousness. On the part of the digestive tract: epygastralnye pain , nausea, vomiting, diarrhea, constipation, intestinal colic, loss of appetite, there have been cases of perversion of taste sensations, changes in liver function tests. From the hematopoietic system: leukopenia. From the bone-mysh—Ďchnogo system: arthralgia. Allergic reactions: skin rash, itching, hives.

    Overdose

    High doses can cause amplification of side effects, mainly nausea, vomiting, and vertigo; In more severe cases, there may be a ataxia, paresthesias, and seizures, depression.
    In the case of poisoning apply symptomatic and supportive treatment, no specific antidote.

    Interaction with other drugs
    Enhances the effect of coumarin anticoagulants, prolongs the effect of muscle relaxant vecuronium bromide. Compatible with ethanol (not inhibit acetaldehyde dehydrogenase) unlike other imidazole derivatives (metronidazole).

    Cautions
    Patients with severe hepatic insufficiency dianabol side effects should be used with caution, as a result of slowing metabolism dianabol side effects concentration and its metabolites in the plasma increases.
    Due to slow excretion need to be careful when choosing the dose of dianabol side effects in patients with renal insufficiency. In such patients, the dose should be reduced by half.
    dianabol side effects must with great caution in patients with bone marrow depression and central nervous system, as well as in elderly patients.
    The emergence of ataxia, dizziness and any other worsening of neurological status of patients required discontinuation of treatment.
    In the long therapy (more than 10 days) should be monitored picture peripheral blood and liver function.
    When leucopenia the possibility of extending the treatment depends on the risk of infection.
    in the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men should refrain from sexual activity. Be sure to simultaneous treatment of sexual partners. After treatment of trichomoniasis should conduct pilot tests in three successive cycles before and after menstruation.
    After treatment of giardiasis, if symptoms persist after 3-4 weeks is necessary to conduct the analysis of 3 at intervals of feces in a few days (some successfully treated patients with lactose intolerance, caused by infestation may persist for several weeks or months, reminding giardiasis symptoms).

    Form release
    tablets, film-coated 500 mg:
    3 or 10 tablets in blister PVC / aluminum foil.
    According to 1,4,5,7 or 10 blisters 3 tablets in a cardboard box with the instructions for medical use.
    In 1 or 2 blisters of 10 tablets in a cardboard box with the instructions for medical use.

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