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The antimicrobial agent combined (protivoprotozoynoe antimicrobial and antifungal agent +).

pharmacological properties

pharmacodynamics

The drug is a combination of Gaynomaks tioconazole and dianabol pills. Tioconazole – synthetic antifungal agent with high activity against yeast and other fungi (dermatophytes). It is effective against bacteria and pathogens: Trichomonas vaginalis, Gardnerella vaginalis, Bacteroides spp,. Some Gram-positive bacteria (incl. Staphylococcus spp and Sreptococcus .).

Tioconazole mechanism of action is to increase the permeability of the cell membrane of the fungus by inhibiting the synthesis of ergosterol, the major component thereof. Increasing the permeability of the cell membrane gives intracellular ionic balance that leads to cell death. Clinical studies have shown that efficient tioconazole, miconazole both clinical parameters (98% and 78%, respectively), and microbiologically (eradication of the pathogen in the 76% and 67%, respectively). Furthermore, the reception tioconazole compared to miconazole proved 2 times subjectively more comfortable for patients.

dianabol pills is effective against a protozoan pathogens (Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia), and most anaerobic bacteria(Trichomonas vaginalis, Gardnerella vaginalis, Bacteroides fragilis, Bacteroides melaninogenicus, Bacteroides spp., Clostridium spp., Eubacterium spp., Peptostreptococcus spp . and Veillonella spp.).
dianabol pills mechanism of action is not fully understood.

Recovering nitro mediated ferredoksinovoy system and a low redox potential, only produced by anaerobic bacteria. This fact may be the reason that there is an active absorption of dianabol pills in anaerobic than the aerobic, although dianabol pills penetrates through cell membranes like those, and others. When the reduction reaction produces active intermediates and increases the diffusion gradient that enhances the absorption of dianabol pills.

Despite the fact that the cross-resistance is usually characteristic for the group of 5-nitroimidazoles, 65-70% of strains h Trichomonas vaginalis, highly resistant to metronidazole have an increased sensitivity to dianabol pills.

According to clinical studies, the efficacy tioconazole combination with dianabol pills in intravaginal administration is 90-100%, with recovery on microbiological criteria is 85%.

Pharmacokinetics

When both intravaginal application tioconazole and dianabol pills are absorbed slightly. Thus, the absorption of the two drugs in combination should be low.

Indications

Treatment of vaginitis caused by the pathogens of the genera Candida, Trichomonas and of Gardnerella (vaginal candidiasis, Trichomonas vulvovaginitis, gardnerelleznoy vaginitis, nonspecific vaginitis) and mixed infection.

Contraindications

  • Hypersensitivity to the active ingredients or their derivatives, other ingredients;
  • organic diseases of nervous system, now or in history;
  • leukemia, hematopoietic disorders;
  • during pregnancy in the I trimester, lactation
  • virginity under the age of 18 years

Application of pregnancy and during breastfeeding

dianabol pills penetrates the fetoplacental barrier and into breast milk. The effects of the components of this drug on the fetus and newborn development are not known.
Of the drug is contraindicated in the Reception Gaynomaks I trimester of pregnancy. At the time of treatment drugs Gaynomaks should stop breastfeeding.
Use of the drug Gaynomaks in the III trimester of pregnancy should be evaluated by the attending physician with the position relation of the potential benefit to the mother and the possible risk to the fetus.

Dosing and Administration

. Intravaginal
drug appoint 1 vaginal suppository at night for 7 days
Alternative reception scheme. 1 vaginal suppository 2 times a day (morning and night) for 3 days
Vaginal Suppositories should be administered deep into the vagina using a disposable fingertips contained packaged.

Elderly patients
In appointing the drug to patients of advanced age (over 65 years) changes in the dosing regimen is required.

Side effect

Side effects according to the results of clinical trials.

In clinical studies, the combination dianabol pills 150 mg 100 mg tioconazole form of a cream or vaginal tablets, clinical and microbiological parameters were evaluated at a total of 348 patients were evaluated both reception circuit (3 or 7 days).

According to the research the safety of this combination has been assessed as high. The observed side effects: allergic reactions (3,3-4,5% of cases), local pruritus (1.9%) and burning sensation (1.7%). In most cases, the side effects of moderate severity had only 0.75% of patients discontinued treatment due to allergic reactions.

Post-marketing experience with

In post-marketing practice, use of the drug is further reported the following adverse events:

Local reactions:
rarely – swelling, irritation of the vaginal mucosa.

From the central and peripheral nervous system:
rarely – headache, fatigue.

From the mochevyvodyaschei system:
rare – dark urine

Allergic reactions:
seldom – skin rash, urticaria, in some cases – angioedema.

Although intravaginal application tioconazole combination with dianabol pills, there was not one case of transient leukopenia, described cases of this symptom, coupled with the neurological or gastrointestinal symptoms associated with systemic use of dianabol pills.

Overdose

In case of accidental ingestion of large amounts of the drug carried out gastric lavage. There is no specific antidote, symptomatic therapy.

Interaction with other drugs

Simultaneous treatment of alcohol and dianabol pills formulated for systemic action may cause intestinal colic, nausea and vomiting, skin redness.
Despite the fact that the use dianabol pills composition pessaries minimizes delivery of the drug into the systemic circulation, interaction with alcohol must be considered when administering the drug.

special instructions

Despite the fact that in clinical studies were found resistant hematological disorders during treatment with the drug, dianabol pills can not be taken for patients with diseases of the hematopoietic system (leukemia, hematopoietic disorders) now or in history.

Gaynomaks The drug should not be used simultaneously with the mechanical means of contraception (condoms, contraceptive diaphragm or cap), as suppository base may be reacted with a latex basis of these means.

Drinking alcohol should be avoided during administration of the drug, as well as within 2 days after the last dose.

The drug should not be stored in the refrigerator.

Effects on ability to drive vehicles and mechanisms

Admission Gaynomaksa drug does not affect the ability to drive and use machines.

release Form

Vaginal suppositories 150 mg + 100 mg.
7 suppositories contour bezgyachakova packaging PVC / LDPE.
In one contour bezgyachakova package complete with 7 disposable fingertips, packed in a transparent plastic bag, together with instructions for use in paper cartons. buy testosterone online deca grega steroids pills